Endocrine Abstracts

Introduction: The aim of this study was to evaluate predictors of metabolic disease in normal weight postmenopausal women.Patients and Methods: This cross-sectional study included 457 non-obese postmenopausal women, recruited from the Menopause Clinic of Aretaieio Hospital, National and Kapodistrian University of Athens. The diagnostic criteria of the International Diabetes Federation for the definition of Metabolic Syndrome were used, in order to classi...

Introduction: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Patients and Methods: This cross-sectional study included 420 ...

Introduction: The hypothalamic-pituitary-ovarian and/or adrenal axis as well as the autonomous nervous system affect significantly the intensity of menopausal symptoms Pre-existing levels of stress may affect the individual perception of menopausal symptoms. We aimed to evaluate the efficacy of a structured stress management program to reduce levels of stress and severity of climacteric symptoms, in a sample of middle-aged Greek women.Methods: The sample...

IntroductionRecent evidence suggests a possible link between prediabetes and lower density in postmenopausal populations. Moreover, earlier data suggest a link between diagnosis of diabetes and lower levels of bone density in women after the menopausal transition. We aimed to evaluate the possible association between insulin resistance and a diagnosis of lumbar or hip osteoporosis and/or prevalent fractures of the lumbar spine. Met...

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

Background: Hyperthyroidism often presents with aberrant liver function. The differential diagnosis of this presentation includes thyrotoxicosis-associated liver dysfunction or antithyroid drug-induced liver dysfunction. We present a case where Propylthiouracil treatment resulted in acute liver failure.Case Presentation: A female patient diagnosed with Grave’s disease in August 2023 initially received carbimazole but discontinued this due to vomitin...

Background: Cardiovascular disease remains the leading cause of death worldwide, affecting both sexes. Awareness and prevention practices aiming to control cardiovascular risk in women remain inadequate. On the other hand, circulating amyloid β 1-40 (Aβ1-40) is a proatherogenic peptide, closely linked with the process of aging. We aimed to evaluate the possible association between the progression of atherosclerosis in postmenopausal women and the role of Aβ1-40 ...

Introduction: Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours with no standardised protocol for treatment. 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) is an emerging treatment option for patients with metastatic and/or inoperable PPGL, and with low toxicity. We present our experience with PRRT in advanced PPGL, treated in a ENETS Centre of Excellence.Materials and Methods: 165 patients with...

Introduction: Gestational trophoblastic disease (GTD) is a group of disorders arising from abnormal proliferation of placental trophoblasts. Hydatiform mole (molar pregnancy) is a premalignant condition which is further devided in to partial and complete mole. Incidence of molar pregnancy is estimated to be 1 in 1000 pregnancies. Hyperthyroidism is one of the rare complications of molar pregnancy which, if not detected and treated, can lead to adverse consequences. We describe...